响应面设计试验法优化复方左旋肉碱涂膜剂的制剂处方

何群, 李湘璐, 王适, 吕毅, 钟鸣, 杨崧

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (8) : 655-660.

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中国药学杂志 ›› 2017, Vol. 52 ›› Issue (8) : 655-660. DOI: 10.11669/cpj.2017.08.009
论著

响应面设计试验法优化复方左旋肉碱涂膜剂的制剂处方

  • 何群1,2, 李湘璐1, 王适3, 吕毅4, 钟鸣1, 杨崧1*
作者信息 +

Optimization of Formulation of Compound L-Carnitine Coating Agent by Response Surface Design Method

  • HE Qun1,2, LI Xiang-lu1, WANG Shi3, Lü Yi4, ZHONG Ming1, YANG Song1*
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文章历史 +

摘要

目的 优化复方左旋肉碱涂膜剂的制剂处方,为工业化生产提供依据。方法 以涂膜剂成膜时间为评价指标,在单因素试验的基础上,采用星点设计试验法优选成膜材料丙烯酸树脂Ⅱ及增塑剂甘油的最优配比。结果 单因素试验及星点设计试验结果可知,涂膜剂成膜材料为15.4%丙烯酸树脂Ⅱ,增塑剂为10.4%甘油。结论 本实验筛选出复方左旋肉碱涂膜剂制剂处方最优配比与用量,可供该制剂成型工艺及透皮试验研究参考。

Abstract

OBJECTIVE To provide a theoretical basis for industrialized production of compound L-carnitine coating agent by optimizing the prescription. METHODS Using the time of coating formation as the evaluation index, Central composite design was used to optimize the ratio of film-former and plasticizer on the basis of single factor experiments. RESULTS The film-former is 15.4% acrylic resin Ⅱ, and the plasticizer is 10.4% glycerin. CONCLUSION In this paper, the optimal formulation and dosage of compound L-carnitine coating agent was screened. This formulation can provide reference for the molding process of the preparation and the experiment of percutaneous absorption.

关键词

复方左旋肉碱涂膜剂 / 响应面设计试验法 / 成膜时间 / 丙烯酸树脂Ⅱ

Key words

Compound L-carnitine coating agent / Response surface design method / Film forming time / Acrylic resin Ⅱ

引用本文

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何群, 李湘璐, 王适, 吕毅, 钟鸣, 杨崧. 响应面设计试验法优化复方左旋肉碱涂膜剂的制剂处方[J]. 中国药学杂志, 2017, 52(8): 655-660 https://doi.org/10.11669/cpj.2017.08.009
HE Qun,LI Xiang-lu,WANG Shi,Lü Yi,ZHONG Ming,YANG Song*. Optimization of Formulation of Compound L-Carnitine Coating Agent by Response Surface Design Method[J]. Chinese Pharmaceutical Journal, 2017, 52(8): 655-660 https://doi.org/10.11669/cpj.2017.08.009
中图分类号: R944   

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长沙市科技局计划项目(K0803123-21)
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