目的 优化复方左旋肉碱涂膜剂的制剂处方,为工业化生产提供依据。方法 以涂膜剂成膜时间为评价指标,在单因素试验的基础上,采用星点设计试验法优选成膜材料丙烯酸树脂Ⅱ及增塑剂甘油的最优配比。结果 单因素试验及星点设计试验结果可知,涂膜剂成膜材料为15.4%丙烯酸树脂Ⅱ,增塑剂为10.4%甘油。结论 本实验筛选出复方左旋肉碱涂膜剂制剂处方最优配比与用量,可供该制剂成型工艺及透皮试验研究参考。
Abstract
OBJECTIVE To provide a theoretical basis for industrialized production of compound L-carnitine coating agent by optimizing the prescription. METHODS Using the time of coating formation as the evaluation index, Central composite design was used to optimize the ratio of film-former and plasticizer on the basis of single factor experiments. RESULTS The film-former is 15.4% acrylic resin Ⅱ, and the plasticizer is 10.4% glycerin. CONCLUSION In this paper, the optimal formulation and dosage of compound L-carnitine coating agent was screened. This formulation can provide reference for the molding process of the preparation and the experiment of percutaneous absorption.
关键词
复方左旋肉碱涂膜剂 /
响应面设计试验法 /
成膜时间 /
丙烯酸树脂Ⅱ
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Key words
Compound L-carnitine coating agent /
Response surface design method /
Film forming time /
Acrylic resin Ⅱ
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中图分类号:
R944
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参考文献
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脚注
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基金
长沙市科技局计划项目(K0803123-21)
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